Well grant I know what you are going through? For the last 13 years I have had relapsing Drug Psychosis from ill-prescribed medication that my body can’t break down. I will share with you page 4 of my CYP450 test which shows that I only have cytochrome 1 & 2 active and when they are partially active it is pretty much considered in-active. The CYP450 test checks the allele that can and are active in your body. If you are given a drug which isn’t in your cytochrome (allele) type, it breaks down more or less randomly locking to the wrong proteins to be vented from the body. In my case my body doesn’t vent chemical very well (This covered in the CYP450 test) which means these proteins with random chemical bonds stays around for up to a decade and then they bond with other proteins with random chemical bonds also from food additive, even fluoride in the water and so on, and make me neurotoxic, otherwise known as a Drug Psychosis, where you have though delusions and symptoms very similar to schizophrenia with traits of bipolar with emotional highs and lows. You will see my CYP450 test I only have cytochrome 1 & 2 which is a poor metaboliser, most people have either 4 or 6 and this was told to me also as a 14 year old doing the pulmonary test when it was being developed Australia wide, when I was doing primary school work experience at the Hornsby Hospital genetics labs.
With stilnox (Zolpidem) doing some research online with Google requires cytochrome (allele) 6 & 4 to break down correctly nih.gov has an interesting article just remember different people taking Stilnox often have very different reactions. One person may tolerate Stilnox well but not get the desired effect, another may have side effects or adverse reactions that make Stilnox intolerable, and yet another may get the desired effect with no side effects. These variations in response and side effects are caused by many variables, but genetic variation and metabolism-based drug, herbal, and food interactions are among the most common.
If Stilnox is a major or exclusive substrate for CYP2D6, CYP2C9, CYP2C19, CYP1A2, NAT2, or DPD; DNA testing can be ordered that can help your healthcare provider predict your response to this medication. To determine if testing may be advisable and ask for DNA Drug Sensitivity Testing information. CYP450 included with each DNA test so your healthcare providers can predict the cumulative effect of metabolism variables of concurrent medications, DNA test results, over-the-counters, foods, herbals, and other relevant patient factors.
Drugs are metabolized by the body in much the same way as food, herbals, and environmental pollutants; they are broken down by liver and gut enzymes or other mechanisms so they can be absorbed and eliminated in the bile and urine. Enzymes are available to metabolize specific substances- a medication is referred to as a substrate of the enzyme that can metabolize it. Often an enzyme will be capable of breaking down more than one substance, but sometimes if two or more drugs that use the same enzyme are taken (and metabolized) at the same time, an interaction can occur. Enzyme-related drug interactions can be brought about because some drugs, called inducers, increase the activity of an enzyme and others, called inhibitors, reduce it. Additionally, genetics can determine your inborn ability to create many of the enzymes in the liver or gut, and the amount of an enzyme that is available can dramatically alter how you process medication. Approximately 50% of individuals have inherited DNA alterations that can affect how they process the majority of the most commonly prescribed medications.
This test not being done on patients before any form of prescription is done, has lead to hundreds of thousands of suicides, homicides as well as relapse and hospitalisation where if done would have been avoided, for me it means there is very little I can take and the medication I currently have somewhere in the dark quiet recesses of my mind I have buried the suicidal thoughts associated with my neurotoxic state! This is very typical of Antipsychotics, Antidepressants and Mood Stabilisers!